Controlling columnar order in a discotic liquid-crystal by kinetic arrest of disc tumbling. Chen, Zhenxua Bishop, Camille Thoms, Erik Bock, Harald Ediger, Mark Richert, Ranko Yu, Lian.Prolific Polymorph Generator ROY in Its Liquid and Glass: Two Conformational Populations Mirroring the Crystalline-State Distribution. Amorphous drug-polymer salt with high stability under tropical conditions and fast dissolution: The case of lumefantrine-PAA. Xin Yao, Soojin Kim, Yue Gui, Zhenxuan Chen, Junguang Yu, Lian Yu.Perspective: Amorphous Drug-Polymer Salts. Structure of supercooled glycerol, xylitol, and D-sorbitol by synchrotron X-ray scattering and relation to dynamic fragility. Zhenxuan Chen, Chengbin Huang, Xin Yao, Chris J.Crystal energy landscape of nifedipine by experiment and computer prediction. Surface diffusion is controlled by bulk fragility across all glass types. Surface Enrichment of Surfactants in Amorphous Drugs: An X-Ray Photoelectron Spectroscopy Study. Structure of Glasses Created by Multiple Kinetic Arrests. Yu, Junguang Chen, Zhenxua Teerakapibal, Rattavut Benmore, Chri Richert, Ranko Yu, Lian.Surface diffusion of a glassy discotic organic semiconductor and the surface mobility gradient of molecular glasses. Computational Materials Science 2022, 206, 111304. Compositional Trends in Surface Enhanced Diffusion in Lead Silicate Glasses. Ajay Annamareddy Manel Molina-Ruiz Donez Horton-Bailey Frances Hellma Yuhui Li Lian Yu Dane Morgan.Polymorphic Selectivity in Crystal Nucleation. Kinetics of Surface Enrichment of a Polymer in a Glass-Forming Molecular Liquid. Issue “Crystallizing the Role of Solid-State Form in Drug Delivery”. Effect of Surfactants on Crystal Nucleation and Growth of Amorphous Nifedipine. Solvent-mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen. Hernández Espinell, José Toro, Veronica Yao, Xi Yu, Lia López-Mejías, Vilmalí Stelzer, Torsten.Anisotropic Molecular Organization at a Liquid/Vapor Interface Promotes Crystal Nucleation with Polymorph Selection. Influence of moisture and surfactants on surface dynamics of amorphous drugs: A concentration-temperature superposition principle. Surface Enhancement of Crystal Nucleation in Amorphous Acetaminophen. ROY: Using the Method of Molecular Voronoi−Dirichlet Polyhedra to Examine the Fine Features of Conformational Polymorphism. Surface-enhanced crystal nucleation and polymorph selection in amorphous posaconazole. Amorphous Drug-Polymer Salts: Maximizing proton transfer to enhance stability and release. We are developing amorphous pharmaceuticals that are stable in hot and humid environments for global health applications. We study the stability of glasses against crystallization, the role of surface mobility in glass crystallization and manufacturing, and the ability to create glasses with tunable liquid-crystalline order. Glasses are remarkable materials with solid-like strength and liquid-like uniformity with applications in pharmaceutics, electronics, and bio-preservation. Some questions being investigated include: Why do some molecules have many polymorphs and others seemingly none? Why do polymorphs nucleate and grow from the same liquid at very different rates? How does a liquid/vapor interface influence crystallization and polymorph selection? Polymorphism is the ability of the same molecule to crystallize in different structures and an important phenomenon for all crystalline materials because polymorphs have different properties. They exhibit physical phenomena unknown for hard materials and offer new opportunities for materials engineering. These materials contain complex molecules assembled by many types of intermolecular forces. We study the solid materials of organic molecules important for pharmaceutical formulations and electronic devices.
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